Long non-coding RNA in spermatogenesis regulation and male infertility:Progress in research
LI Li-bing
SUN Li-lan
MA Hua-gang
Abstract：Long non-coding RNA(lncRNA)is an RNA molecule transcribed by RNA polymerase lI,longer than 200 nt,and not translated into proteins.During gonadal development and spermatogenesis,lncRNAs are involved in epigenetic mechanisms,inclu-ding DNA methylation,chromatin remodeling,and histone tail modification,which play important regulatory roles at the transcriptional or post-transcriptional level.Epigenomics including lncRNA is considered to be the second dimension of DNA sequence that can be a-dapted to environmental factors to specifically regulate gene expressions in some cells.Based on the functional action mechanism of ln-cRNAs,we reviewed the advances in the studies of lncRNAs in the direction of spermatogenesis and male infertility and analyzed the potential of lncRNAs as a biomarker of male infertility.The potential application of lncRNA in the treatment of male infertility diseases can be further explored based on the lncRNA target,RNA interference,competitive binding closed target and structural disruption of lncRNAs.
Keywords：long non-coding RNAmale infertilityspermatogonia proliferationspermatogonia differentiationspermatocyte meiosispotential therapeutic target
Publication Date：2023-03-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 269-274 )