Correlation of serum androgen levels with lipid metabolism in middle-aged and elderly men in Zunyi, Guizhou

SHEN Xu-bo; XIONG Shi-min; LIU Fang-wei; SHI Yong-jun; YU Qin; LI Quan; SHEN Lian-bo; ZHOU Yuan-zhong

doi:10.13263/j.cnki.nja.2018.04.004

Abstract：Objective:To investigate the relationship of the levels of serum androgens with lipid metabolism in middle-aged and elderly men in Zunyi,Guizhou.Methods:Using the stratified cluster sampling method,we conducted a questionnaire investigation and physical examinations among 437 men in Zunyi City.We divided the subjects into a middle-aged (40-64 [53.20 ± 7.41]years,n =269) and an elderly group (≥65 [70.63 ± 4.66] years,n =168) and collected fasting elbow venous blood samples from them for measuring the levels of total testosterone (TT),sex hormone-binding globulin (SHBG),luteinizing hormone (LH),total cholesterol (TCH),triglyceride (TG),high-density lipoprotein (HDL),low-density lipoprotein (LDL),calculated free testosterone (cFT),free testosterone index (FTI),and testosterone secretion index (TSI).Results:Compared with the elderly group,the middle-aged males showed significantly lower SHBG,LH,HDL and LDL,and higher cFT,FTI,TSI,TG and TCH (all P ＜ 0.05).TT and SHBG were negatively correlated with TG,TCH,HDL and LDL,while cFT was positively correlated with TCH,and so was FTI with TG,TCH with LDL,and TSI with TCH,HDL and LDL (all P ＜ 0.05),but LH was negatively correlated with TG,TCH and LDL (all P ＜ 0.05).Multivariate linear regression analysis showed that TT and SHBG were negatively correlated with TG,TCH,HDL and LDL,and so was LH with TCH,HDL and LDL (all P ＜ 0.05).Conclusion:In the middle-aged and elderly men in Zunyi,low concentrations of TT,SHBG and LH were associated with the increased risk of high-TCH and-LDL dyslipidemia,low concentrations of TT and SHBG with that of high-TG dyslipidemia,while high concentrations of TT,SHBG and LH with that of low HDL dyslipidemia.