Impact of inhaled anesthetics on the male reproductive system and its mechanisms: An update
ZHOU Hai-yan
MO Xian-gang
ZOU Xiao-hua
Abstract：The safety of occupational exposure to inhaled anesthetics remains a concern among the medical staff in hospitals.Few reports are seen about the impact of inhaled anesthetics on the reproductive system,particularly that of males.Several clinical and basic studies on isoflurane and others suggest that inhaled anesthetics affect the reproductive system of rodents by decreasing the sperm count,inducing sperm morphological abnormality,reducing sperm motility,and changing the levels of reproductive hormones,the underlying mechanisms of which are mainly associated with the alteration of the hypothalamic-pituitary-gonadal axis and DNA damage and apoptosis of reproductive cells.This article reviews the main impacts of inhaled anesthetics on the male reproductive system and the possible mechanisms.
Keywords：isofluranesevofluranedesfluranemale reproductive systemreproductive hormones
Publication Date：2018-03-02
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 272-276 )