Relationship between the FSHR Thr307Ala-Asn680Ser gene polymorphism and male infertility: A meta-analysis

LUO Jun; WANG Lin; SHI Heng-chuan; ZENG Qing-qi; WU Qiu-yue; LI Wei-wei

doi:10.13263/j.cnki.nja.2017.12.014

Abstract：Objective:To assess the association of the FSHR Thr307Ala-Asn680Ser gene polymorphism with male infertility.Methods:We searched Pubmed,EMBASE,Web of Science,CNKI,and WANFANG databases for literature on the correlation of the FSHR Thr307Ala-Asn680Ser gene polymorphism with male infertility published from 2005 to the present time.According to the inclusion criteria,we included 12 epidemiological case-control studies and subjected them to a comprehensive analysis with the Stata11.0 software.Results:A total of 2 893 male infertility patients and 3 312 controls were involved in the 12 studies.The Thr307Ala (rs6165) gene polymorphism was shown to be a risk factor for male infertility among the three comparison models (homozygous comparison model,hybrid comparison model and dominant comparison model),with the pooled odds ratios (OR) of 1.26 (95 ％ CI:1.03 -1.54,P =0.023),1.18 (95％ CI:1.03-1.36,P =0.018),and 1.20 (95％ CI:1.05-1.37,P =0.006),respectively.And the Asn680Ser(rs6166) polymorphism was a risk factor for male infertility in the homozygous comparison and recessive comparison models,with the pooled ORs of 1.24,(95％ CI:1.05-1.45,P =0.009) and 1.20 (95％ CI:1.04-1.39,P =0.013),respectively.Layered meta-analysis showed that in the homozygous comparison model,the Thr307Ala-Asn680Ser polymorphism is a risk factor for male infertility in the white population,with the OR of 1.37 (95％ CI:1.03-1.82,P =0.003) and 1.21 (95％ CI:1.00-1.47,P =0.048),respectively.Conclusion:In the homozygous model (GG vs AA),the FSHRThr307Ala-Asn680Ser gene polymorphism might be a protective factor against male infertility.