Microdissection testicular sperm extraction for patients with nonmosaic Klinefelter syndrome: A report of 143 cases
MAO Jia-ming
ZHAO Lian-ming
HONG Kai
TANG Wen-hao
LIU De-feng
LIN Hao-cheng
WU Han
ZHANG Hai-tao
ZHANG Hong-liang
YANG Yu-zhuo
WANG Ya-peng
LIAN Ying
JIANG Hui
MA Lu-lin
QIAO Jie
Abstract：Objective:To investigate the clinical application and outcomes of microdissection testicular sperm extraction (micro-TESE) in patients with nonmosaic Klinefelter syndrome (KS).Methods:A total of 143 nonmosaic KS patients underwent microTESE in the Center of Reproductive Medicine of Peking University Third Hospital between July 2012 and August 2016.We analyzed their clinical and follow-up data and evaluated the outcomes.Results:Spermatozoa were successfully retrieved from the testicular tissue in 44.76％ (64/143) of the patients,84.4％ (54/64) by unilateral and 15.6％ (10/64) by bilateral micro-TESE.Seventy-five of the KS patients were followed up in the years of 2014 and 2015.Of the 34 patients with successful sperm retrieval,73.52％ (25/34) achieved clinical pregnancy and 8 boys and 8 girls were already born in 14 of the 25 cases.Conclusion:The micro-TESE is a useful method for sperm retrieval in nonmosaic KS patients,with high rates of sperm retrieval,clinical pregnancy,and birth of biological offspring.
Keywords：microdissection testicular sperm extractionKlinefelter syndromenon-obstructive azoospermiasperm retrievalpregnancy rate
Publication Date：2017-12-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1075-1079 )