Correlation of serum zinc alpha 2 glycoprotein with blood lipid and reproductive hormone levels in men

YANG Chao-ju; HAN Rui-yu; WANG Shu-song

doi:10.13263/j.cnki.nja.2017.11.007

Abstract：Objective:To study the changes of the serum zinc alpha 2 glycoprotein (ZAG) level in men and its relationship with blood lipid male reproductive hormones.Methods:We enrolled 297 men aged 25-65 years in this study,152 with hyperlipemia (HL) and the other 145 with normal blood lipid (normal control).We divided them into four age groups (25-35 yr,36-45 yr,46-55 yr,and 56-65 yr) and three tertile groups (Q1,Q2,and Q3) according to the tertiles of the serum ZAG level,and examined their blood lipid,blood glucose,serum ZAG,and reproductive hormones.Results:The serum ZAG level was decreased gradually with the increase of age in both the HL patients and normal controls,significantly in the 36-45 and 56-65 yr age groups (P ＜ 0.05),and markedly lower in the HL than in the control men in the 25-35 and 36-45 yr groups (P ＜ 0.05).The levels of follicle-stimulating hormone (FSH) and total testosterone (TT) changed significantly with the ZAG level.The level of serum ZAG was correlated negatively with age (r =-0.58,P ＜0.05),waist circumference (r =-0.21,P ＜0.05),body mass index (BMI) (r =-0.22,P ＜0.05),fasting blood glucose (r =-0.16,P ＜0.05),and triglyceride (TG) (r =-0.27,P ＜0.05) but positively with TF (r =0.36,P ＜ 0.05).Age,BMI and TG were independent factors influencing the serum ZAG level.Conclusion:The serum ZAG level is decreased with the increase of age and associated with lipid metabolism,abdominal obesity,and reproductive hormone levels in males.