TDP-43 in male infertility: Progress in studies
CHENG Peng
Abstract：Approximately 10-15％ of couples worldwide fail to achieve a pregnancy within a year after marriage.Male factors account for about 50％ of the causes of infertility and the causes of male infertility are complicated and varied,and many of them are not yet clear.In recent years,the role of RNA-binding proteins in male infertility has attracted much attention.The transactive response DNA-binding protein of 43 kDa (TDP-43) is involved in gene regulation in the testis,and its abnormal expression may affect male reproduction and lead to male infertility.The distribution and expression of TDP-43 vary in normal and abnormal spermatozoa and may be a marker of male infertility.This article presents an overview on the structure of TDP-43 and its role in male infertility.
Keywords：transactive response DNA-binding protein of 43 kDamale infertilityDNA/RNA-binding proteinacrosomal vesicle protein 1transcriptional repressor
Publication Date：2017-10-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 942-945 )