Clinical treatment of erectile dysfunction in type 2 diabeticpatients in the high-altitude area

LI Fu-dong; ZHANG Bin; WANG Yang-min

doi:10.13263/j.cnki.nja.2017.10.003

Abstract：Objective:To investigate the safety and efficacy of pancreatic kininogenase combined with sildenafil in the treatment of erectile dysfunction (ED) in type 2 diabetes mellitus (DM) patients in the high-altitude area.Methods:This study included 93 ED patients with type 2 DM,all residents of the Xining area 1500 meters above sea level.We randomly divided them into an experimental group (n =48) and a control group (n =45),the former treated with pancreatic kininogenase (120 u,tid) and sildenafil (25 mg,qd at bedtime),while the latter with sildenafil only (25 mg,qd at bedtime).After 4 and 8 weeks of medication,we obtained the penile hemodynamic parameters,IIEF-5 scores,and sexual intercourse satisfaction(SIS) scores and compared them between the two groups of patients.Results:There were no statistically significant differences in age or DM course between the two groups of patients (P ＞ 0.05).Compared with the baseline,both the experimental and control groups showed remarkably improvement inthe IIEF-5 score (8.81 ± 2.06vs11.54 ± 7.72 and 8.29 ± 1.91 vs9.37± 1.65,P ＜0.05),SIS score (3.35 ± 2.43vs6.83± 2.61and3.41 ± 2.38 vs 4.92± 2.49,P ＜0.05),and penile hemodynamic parameters obtained by color duplex Doppler ultrasonography(P ＜ 0.05),with significant differences between the two groups in the IIEF-5 score (11.54 ± 7.72 vs 9.37 ± 1.65,P ＜ 0.05) and SIS score (6.83 ± 2.61 vs 4.92 ± 2.49,P ＜ 0.05) but not in the penile hemodynamic parameters (P ＞ 0.05).Even more remarkable improvement was observed at 8 weeks in the experimental and control groups in the IIEF-5 score (19.29 ± 1.85 and 15.43 ± 1.74) (P ＜ 0.05),SIS score (11.73 ± 2.57 and 6.55 ± 2.71) (P ＜ 0.05),and penile hemodynamie parameters (P ＜ 0.05),all with significant differences between the two groups (P ＜ 0.05).Conclusion:Pancreatic kininogenase combined with sildenafil has a bet-ter clinical effect than sildenafil alone on ED in type 2 DM patientsin the high-altitude area.