Sperm mitochondrial DNA and male infertility: An update
LI Gang-qin
Abstract：Sperm mitochondrial DNA (mtDNA) damage is closely related with male infertility.Lacking for the protection by histone and DNA-binding protein,sperm mtDNA is prone to the attack by reactive oxygen species (ROS) and,without an effective repair system of mtDNA,ROS-induced changes in mtDNA may damage the synthesis of mtDNA encoding proteins and affect the function of mitochondria,which may be an important genetic factor for male infertility.Related studies should focus on finding the causes of sperm mtDNA damage and its relationship with male infertility.
Keywords：spermmitochondrial DNAmale infertility
Publication Date：2017-09-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 848-851 )