Association of abnormal length of Y chromosome with semen quality and outcome of assisted reproductive technology in humans
LI Bin-ye
ZHANG Yong-tian
ZENG Xiang-hui
L(U) Jin-chun
Abstract：Objective:To investigate the association of the abnormal length of human Y chromosome with semen quality and the outcome of assisted reproductive technology (ART).Methods:Based on the karyotype,we assigned the patients undergoing ART to a normal control,a long Y chromosome (Y ＞ 18),and a short Y chromosome group (Y ＜ 22).We compared the semen parameters and numbers of embryos and high-quality embryos among the three groups of patients and performed statistical analysis of the obtained data using Chi-square distribution and t-test.Results:Compared with the control,the Y ＞ 18 group showed a significantly lower incidence rate of asthenozoospermia (31.03％ vs 8.33％,P ＜ 0.05) and a larger number of high-quality embryos (5.46 ± 4.54 vs 7.40 ± 5.49,P ＜ 0.05).Both the incidence rate of azoospermia and number of total embryos were remarkably lower in the control than in the Y＜22 group (1.87％ vs 16.47％,P ＜0.05;8.60 ± 7.03 vs 10.00 ± 6.58,P＜0.05).No statistically significant differences were found in the pregnancy rate between the Y ＞ 18 and Y ＜ 22 groups (P ＞ 0.05).Conclusion:Short Y chromosome may affect spermatogenesis,but the length of Y chromosome does not negatively influence the outcome of ART.
Keywords：long and short Y chromosomessemen parametersoutcome of assisted reproductive technology
Publication Date：2017-09-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 817-820 )