CatSper in sperm hyperactivation and male infertility: Advances in studies
YANG Lin
CHEN Hai-xia
MU Xiao-huan
Abstract：The CatSper channel is known as one of the most important Ca2+ channels on the cell membrane of mammalian sperm and plays a key role in the motility,hyperactivation and fertilization function of sperm.The CatSperprotein,expressed exclusively in the principal piece of the sperm tail,is composed of CatSper1-4 and 5 auxiliary units[,Υ,δ,ε and ζ,andhas an essential part in the functional and structural domains of Ca2 + as well as in the spatiotemporal regulation of the P-Tyr protein,sperm hyperactivation,efficient sperm migration in the oviduct,egg penetration,and normal fertility.Recent studies show that functional deficiency of CatSper seriously affects sperm function,and the loss of any one of its 9 subunits may lead to male reproductive dysfunction.This paper outlines recent advances in the studies of the CatSperprotein,focusing on its expression,location,structure,and regulation,as well as itsinfluence on sperm hyperactivation and male reproduction.
Keywords：Ca2 +CatSper channelspermhyperactivationmale infertility
Publication Date：2017-08-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 751-756 )