Orchidopexy increases the levels of serum anti-Müllerian hormone and inhibin B in cryptorchidism patients

CAO Shun-shun; HU Yang-yang; NAN Cun-jin

doi:10.13263/j.cnki.nja.2017.08.008

Abstract：Objective:To investigate the levels of serum anti-Müillerian hormone (AMH) and inhibin B (INHB) in patients with unilateral cryptorchidism before and after orchidopexy.Methods:This study included 58 cases of unilateral cryptorchidism treated by orchidopexy and 32 healthy controls.Before and at 6 months after surgery,we measured the length and circumference of the penis,the volume of the undescended testis,and levels of serum AMH and INHB.Results:There were statistically significant differences between the unilateral cryptorchidism and healthy control groups in the levels of serum AMH ([102.80 ± 17.35 vs 108.76 ± 13.64] ng/ml,P ＜0.05) and INHB ([70.24 ± 5.73] vs [77.72 ± 5.94] pg/ml,P ＜0.05) at the baseline,but not at 6 months after orchidopexy (AMH:[109.76 ± 17.25] vs [108.03 ± 14.13] ng/ml,P ＞0.05;INHB:[75.76 ± 5.94] vs [77.63 ± 5.99] pg/ml,P ＞ 0.05).No remarkable differences were observed between the unilateral cryptorchidism and healthy con-trol groups in the preoperative penile length ([2.05 ± 0.23] vs [2.11 ± 0.22] cm,P ＞ 0.05),penile circumference ([3.91 ± 0.23] vs [3.99 ± 0.20] cm,P ＞0.05) and volume of theundescended testis ([0.45 ± 0.02] vs [0.46 ± 0.02] ml,P ＞ 0.05),or in the postoperative penile length ([2.09 ± 0.23] vs [2.16 ± 0.22] cm,P ＞0.05),penile circumference ([4.00 ± 0.25] vs [3.98 ± 0.19] cm,P ＞0.05) and volume of the undescendedtestis ([0.45 ± 0.02] vs [0.45 ± 0.02] ml,P ＞ 0.05).Compared with the baseline,the cryptorchidism patients showed markedly increased levels of serum AMH ([102.80 ± 17.35] vs [109.76 ± 17.25] ng/ml,P ＜0.05) andINHB ([70.24 ± 5.73] vs [75.76 ± 5.94] pg/ml,P ＜0.05) afterorchidopexy.Conclusion:Orchidopexy can elevate the levels of serum AMH and INHB and protect the testicular function of cryptorchidism patients.