Qilan Capsules plus androgen-deprivation therapy for Qi-deficiency blood-stasis type of prostate cancer after castration

CHANG De-gui; LI Xiang; ZOU Jian-hua; YU Xu-jun; PAN Xiao-fang; WU Tian-lang; LI Guang-sen; CHEN Wen-ying; CHEN Cheng

doi:10.13263/j.cnki.nja.2017.07.013

Abstract：Objective:To observe the synergistic effect of Qilan Capsules in the treatment of the patient with Qi-deficiency blood-stasis type of prostate cancer receiving androgen-deprivation therapy after castration.Methods:This randomized controlled double-blind study included 246 cases of Qi-deficiency blood-stasis type of prostate cancer after castration,which were randomly divided into an experiment and a control group of equal number to be treated with Qilan Capsules + androgen-deprivation and placebo + androgen-deprivation,respectively.After 6 months of treatment,we compared the International Prostate Symptoms Scores (IPSS),TCM Symptoms Scores (TCMSS),maximal urine flow rate (Qmax),and the level of serum prostate-specific antigen (PSA) between the two groups of patients.Results:Statistically significant differences were observed between the experiment and control groups in the syndrome classification-based efficacy (87.7％ vs 67.9％,P ＜0.05) and total effectiveness rate (86.0％ vs 71.6％,P ＜ 0.05).Compared with the baseline,the experiment group showed remarkable improvement after treatment in TCMSS (17.1 ± 5.1 vs 8.3 ±4.0,P ＜0.05),IPSS (17.7 ±7.5 vs 11.4 ±4.6,P ＜0.05),and Qmax ([10.9 ±4.3] ml/s vs [14.7 ±3.7] ml/s,P ＜ 0.05),and so did the control group (16.8 ± 5.2 vs 11.5 ± 5.2,17.8 ± 6.7 vs 14.6 ± 5.8,and [11.0 ± 4.3] ml/s vs [12.0 ± 4.1]ml/s,P ＜ 0.05).The above three parameters were even more markedly improved in the former than in the latter group (P ＜ 0.05).However,there was no statistically significant difference between the two groups in the improvement of the PSA level after treatment (P ＞ 0.05).Conclusion:Qilan Capsules can significantly enhance the effect of androgen-deprivation therapy in the treatment of Qi-deficiency blood-stasis type of prostate cancer after castration though cannot obviously improve the PSA level.