Impacts of different procedures of testicular sperm retrieval on testicular function and antisperm antibodies in azoospermia patients
HU Yang-yang
WANG Li-yuan
SONG Bo-tian
CHEN Ao-lei
CAO Shun-shun
Abstract：Objective:To investigate the influence of different procedures of testicular sperm retrieval on the levels of serum inhibin B (INHB),antisperm antibodies (AsAb),follicle-stimulating hormone (FSH),and testosterone (T) in patients with azoospermia.Methods:We randomly assigned 210 azoospermia patients to receive testicular sperm extraction (TESE,n =50),testicular sperm aspiration (TESA,n =56),testicular fine needle aspiration (TEFNA,n =64),or microscopic TESE (micro-TESE,n =40).We measured the levels of serum INHB,FSH,and T and the positive rate of AsAb before and at 1 and 3 months after surgery.Results:Compared with the baseline,the levels of serum FSH at 1 and 3 months after surgery showed no statistically significant differences in theTESE ([8.51 ± 4.34] vs [8.76 ± 3.07] and [7.24 ± 3.32] IU/L,P ＞0.05),TESA ([7.70 ± 2.72] vs[7.90 ± 4.57] and [8.04 ± 3.65] IU/L,P ＞0.05),TEFNA ([6.04 ± 3.17] vs [6.08 ± 2.70] and [6.10 ± 3.32] IU/L,P ＞0.05),or micro-TESE group ([6.59 ± 2.74] vs [6.89 ± 1.78] and [6.75 ± 2.57] IU/L,P ＞ 0.05);the positive rate of AsAb (IgM) was significantly increased at 1 month in the TESE (0.00 vs 14.00％,P ＜ 0.05) and micro-TESE groups (2.50％ vs 15.00％,P ＜0.05),while the serum T level markedly decreased in the two groups ([16.52 ± 6.25] vs [9.25 ± 5.76] nmol/L and [14.16 ± 5.45] vs [8.23 ± 4.12] nmol/L,P ＜0.05);the levels of serum INHB were remarkably reduced at 1 and 3 months in the TESE ([70.56 ± 23.17] vs [42.63 ± 15.34] and [44.05 ± 18.47] pg/ml,P ＜0.05),TESA ([68.71 ± 14.74] vs [40.55 ± 20.51] and [42.11 ± 19.34] pg/ml,P ＜0.05),TEFNA ([76.81 ± 27.04] vs [46.31 ± 19.28] and [48.32 ± 20.54] pg/ml,P ＜0.05),and micro-TESE groups ([74.74 ± 28.35] vs [45.27 ± 18.83] and [47.64 ± 28.34] pg/ml,P ＜ 0.05),but with no statistically significant differences among the four groups (P ＞ 0.05).Conclusion:Different procedures of testicular sperm retrieval have different impacts on the testicular function and AsAb in patients with azoospermia.
Keywords：testicular sperm retrievalinhibin Bantisperm antibodyfollicle stimulating hormonetestosterone
Publication Date：2017-07-02
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 620-625 )