Risks of diabetes mellitus and impaired glucose tolerance induced by intermittent versus continuous androgen-deprivation therapy for advanced prostate cancer
ZENG Sheng
LI Zhuo-ping
LI Wei
PU Wei-zhen
LIU Peng
MA Zhi-fang
Abstract：Objective:To investigate the correlation of intermittent androgen-deprivation therapy (IADT) and continuous androgen-deprivation therapy (CADT) for advanced prostate cancer (PCa) with the risks of secondary diabetes mellitus (DM) and impaired glucose tolerance (IGT).Methods:We conducted a retrospective case-control study of the advanced PCa patients treated by IADT or CADT in our hospital from January 2013 to December 2015.Based on the levels fasting blood glucose and 2-hour postprandial blood glucose,results of oral glucose tolerance test,and clinical symptoms of the patients,we statistically analyzed the IADT-or CADT-related risk factors for DM and IGT and the relationship of the body mass index (BMI),hypertension,smoking,and alcohol consumption with secondary DM and IGT.Results:IADT was given to 53 (46.5％) of the patients,aged (69.1 ± 4.3) years,and CADT to 61 (53.5％),aged (70.2 ± 5.7) years.No statistically significant differences were observed in clinical characteristics between the two groups of patients (P ＞ 0.05).BMI,blood pressure,smoking and drinking exhibited no significant influence on the development of DM or IGT either in the IADT (P ＞ 0.05) or the CADT group.The incidence of IGT was significantly lower in the IADT than in the CADT group (P =0.03),but that of DM showed no statistically significant difference between the two groups (P =0.64).Conclusion:Compared with CADT,IADT has a lower risk of IGT and a higher safety in the treatment of advanced prostate cancer.
Keywords：prostate cancerintermittent androgen-deprivation therapycontinuous androgen-deprivation therapydiabetes mellitusimpaired glucose tolerance
Publication Date：2017-07-02
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 598-602 )