Epigenetics of male infertility: An update
ZHANG Qi-jie
XU Jie
Abstract：Epigenetic factors play an important role in male infertility though about 60％-65％ of the disease is idiopathic and its underlying causes are not yet clear.Many studies have indicated that epigenetic modifications,including DNA methylation,histone tail modifications,chromatin remodeling,and non-coding RNAs,may be involved in idiopathic male infertility.Abnormal methylation is associated with decreased sperm quality and fertility.It is known that 1 881 miRNAs are related to male fertility and such non-coding RNAs as piRNA,IncRNA,and circRNA play a regulating role in male reproduction.This review focuses on the value of epigenetics in the etiology and pathogenesis of mate infertility,aiming to provide some evidence for the establishment of some strategies for the treatment and prediction of the disease.
Keywords：male infertilityepigeneticsreproductiondiagnosis
Publication Date：2017-06-02
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 566-569 )