Adipose-derived stem cells for the treatment of penile erectile dysfunction: An update
WANG Yi
WANG Ya-min
CHEN Chen
WANG Yi-chun
Abstract：Adipose-derived stem cells (ADSCs) are pluripotent stem cells isolated from the adipose tissue and have the potential for self-renewal and multi-directional differentiation into neurogenic cells,smooth muscle cells,endothelial cells,and so on.Erectile dysfunction (ED) is a common male sexual dysfunction that has a negative impact on the lives of the patients and their partners.Current treatments of ED include surgery and medication,with oral 5-phosphodiesterase inhibitors as the first-line drugs.However,a small number of the patients are not sensitive to these therapies and cannot be improved or cured pathologically.So far,animal experiments and preclinical trials have confirmed the safety and efficacy of ADSCs,which act on ED though paracrine mechanisms.This review summarizes the advances in the recent 5 years in the studies of ADSCs for the treatment of ED.
Keywords：penisadipose-derived stem cellserectile dysfunction
Publication Date：2017-06-02
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 561-565 )