Effects of different medications with tadalafil on erectile dysfunction in males with primary sexual failure
LI Wen-ji
XU Ming-xi
GUO Jian-hua
CAI Zhi-kang
JIANG Yue-qing
WANG Zhong
Abstract：Objective:To evaluate the effects of three different medications with tadalafil on erectile dysfunction (ED) in young men with primary sexual failure.Methods:This study included 76 male ED patients aged 21-35 years who had primary sexual failure but normal nocturnal penile tumescence and rigidity and failed to respond to psychotherapy.We randomly assigned them to receive oral tadalafil once daily,on demand,or once-daily + on-demand.After 2-3 months of treatment,we evaluated the effects based on the scores of the patients in the five domains of the International Index of Erectile Function (IIEF-5).Results:After medication,all the patients showed significantly increased scores in the four domains of IIEF-5,namely,erectile function,orgasmic function,intercourse satisfaction,and overall satisfaction.The on-demand group achieved even higher scores in erectile and orgasmic functions but alower score in sexual desire than the once-daily group.However,the patients in the once-daily + on-demand group exhibited more significant improvement than those in the other two in all the five domains.Conclusion:Once-daily + on-demand medication with tadalafil can significantly enhance the therapeutic effect on psychogenic ED in young men with primary sexual failure.
Keywords：tadalafilerectile dysfunctionInternational Index of Erectile Functionyoung male
Publication Date：2017-06-02
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 522-526 )