Testosterone Undecanoate Pills improves insulin resistance in type-2 diabetes men with hypogonadism

DI Hong-jie; FAN Yao-fu; ZHANG Hui-feng; LIU Ke-mian; LIU Chao

doi:10.13263/j.cnki.nja.2017.06.006

Abstract：Objective:To evaluate the effects of Testosterone Undecanoate Pills (TUP) on insulin resistance (IR) in type-2 diabetes men with hypogonadism.Methods:We randomly divided 82 type-2 diabetes patients with hypogonadism into a treatment (n =42) and a control group (n =40),both maintaining their glucose-and lipid-reducing therapies,while the former treated orally with TUP in addition.After 6 months of medication,we compared the body mass index (BMI),waist circumference (WC),blood glucose level,HbA1c,lipid profile,IR index obtained by homeostatic model assessment (HOMA-IR),insulin sensitivity index (ISI),sex hormone levels,and sexual function scores between the two groups of patients.Results:Compared with the baseline,the patients in the treatment group showed significant decreases after medication in BMI ([26.71 ± 2.39] vs [25.15 ± 2.28] kg/m2,P ＜0.05),WC ([89.96 ± 9.13] vs [85.03 ± 9.58] cm,P ＜0.05),HbA1C ([7.73 ± 1.31] vs [7.01 ± 1.25] ％,P ＜0.05),and triglyeride ([1.97 ± 0.83] vs [1.41 ± 0.69] mmol/L,P ＜ 0.05),a markedly elevated level of total testosterone ([7.16 ± 2.21] vs [14.22 ± 2.63] nmol/L,P ＜0.05),and remarkable improvement in HOMA-IR (3.76 ± 1.18 vs 2.55 ±1.03,P ＜0.05),ISI (96 ± 51 vs 138 ± 53,P ＜0.05) and total scores of the Aging Males'Symptoms (P ＜0.05).But no significant changes were observed in the scores of the International Index of Erectile Function (IIEF) after treatment (13.28 ± 6.38 vs 14.95 ± 6.08,P ＞ 0.05).Conclusion:TUP can significantly improve insulin resistance in type-2 diabetes men with hypogonadism.