Saw palmetto fruit extract improves LUTS in type ⅢA prostatitis patients

SHAO Yun-peng; XUE Hao-liang; SHEN Bai-xin; DING Liu-cheng; CHEN Zheng-seng; WEI Zhong-qing

doi:10.13263/j.cnki.nja.2017.05.006

Abstract：Objective:To assess the clinical efficacy of the saw palmeuo fruit extract (SPFE) in the treatment of lower urinary tract symptoms (LUTS) in patients with type Ⅲ A prostatitis.Methods:This retrospective study included 54 cases of type Ⅲ A prostatitis treated in the Outpatient Department of our hospital from January to December 2015.The patients were aged 35.06 ± 5.85 years,with a mean disease course of 3.8 ± 2.1 years,and all received oral medication of SPFE Capsules at the dose of 320 mg qd for 12 weeks.We assessed the therapeutic effects by comparing the NIH-chronic prostatitis symptom indexes (NIH-CPSI),voiding diary,International Prostate Symptom Scores (IPSS),and results of urodynamic examination before and after treatment.Results:Compared with the baseline,both NIH-CPSI and IPSS were significantly decreased after medication (27.61 ± 3.76 vs 18.6 ± 5.34,P ＜0.01;20.44 ± 4.51 vs 10.96 ±4.62,P ＜0.01),and urodynamic examination and voiding diary showed dramatic post-medication improvement in the average urinary flow rate ([8.05 ± 1.42] vs [12.05 ± 2.60] ml/s,P ＜0.01),maximum urinary flow rate ([14.22±1.74] vs [21.32±4.51] ml/s,P ＜0.01),residual urine volume ([46.15±16.57] vs [14.55±10.21] ml,P ＜0.01),maximum urethral closure pressure ([76.52 ± 3.53] vs [65.32 ± 4.75] cm H2O,P ＜ 0.01),mean urinary volume ([124.63±40.55] vs [285.93 ± 58.68] ml,P ＜0.01),urination frequency (16.96 ±4.17 vs 8.96±2.50,P ＜0.01),and nocturia frequency (8.94 ± 3.23 vs 3.15 ± 1.90,P ＜ 0.01).No apparent adverse reactions were observed in any of the patients.Conclusion:SPFE Capsules can safely and effectively improve LUTS and thus the quality of life of patients with type Ⅲ A prostatitis.