Expressions of glutathione S-transferase P1 and 4-hydroxynonenal and the progression of prostate cancer
SONG Xu
WANG Rong
XIAO Feng
ZHANG Sheng-xi
GONG Min
WANG Xiu-ling
ZHANG Yun
HUANG Jin-yang
Abstract：Objective:To investigate the expressions of glutathione S-transferase (GSTP1) and tetra-hydroxynonenal (4-HNE) in prostate cancer (PCa) and their clinical significance.Methods:We determined the expressions of GSTP1 and 4-HNE in 40 patients with PCa and another 42 with benign prostatic hyperplasia (BPH) by immunohistochemistry and analyzed their relationship with Gleason grades.Results:The expression rate of GSTP1 was 92.9％ in the BPH tissue,and those in the highly,moderately,and lowly differentiated PCa tissues were 58.3％,20.0％,and 16.7％,respectively,significantly higher in the BPH than in the PCa group (P ＜0.01).However,the positive rate of 4-HNE was only 5.0％ in the BPH tissue,markedly lower than 91.6％,100.0％,and 100.0％ in the highly,moderately,and lowly differentiated PCa tissues (P ＜ 0.01).There was a negative correlation between the expression of GSTP1 and that of 4-HNE in the PCa tissue (r =-2.73,P ＜ 0.01).Conclusion:Expression deletion of GSTP1 and high expression of 4-HNE may play an important role in the progression of prostate cancer.
Keywords：prostate cancerglutathione S-transferase4-hydroxynonenalimmunohistochemistry
Publication Date：2017-05-02
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 412-416 )