Expressions of ERK and p-ERK in advanced prostate cancer
HAN Jian
ZHANG Peng
ZHENG Lei
ZHANG Yong
WANG Ke-nan
FAN Lian-ming
XIE Hua-dong
WANG Shu-ren
ZHANG Zhi-wei
WANG Qi-fei
JIANG Tao
Abstract：Objective:To investigate the expressions of extracellular signal-regulated kinase (ERK) and p-ERK in benign and malignant prostate tissues,and whether it can be used as a marker for the prognosis of advanced prostate cancer (PCa).Methods:Using immunohistochemical Envision,we detected the expressions of ERK1/2 and p-ERK1/2 in 20 cases of benign prostatic hyperplasia (BPH) and 40 cases of advanced PCa and analyzed their correlation with PCa metastasis,Gleason score,PSA level,and prognosis.Results:The expression of ERK1/2 was remarkably higher in the advanced PCa than in the BPH cases (82.5％ vs 55％,P ＜0.05),which was not associated with cancer metastasis,Gleason score,PSA level,or survival time of the patients with advanced PCa,and so was that of p-ERK1/2 (75.0％ vs 35％,P ＜0.05),which was not associated with the Gleason score or PSA level of the PCa patients,either.The expression rates of p-ERK in the metastasis,non-metastasis,survival ＞ 5 yr,and survival ≤ 5 yr groups were 61.9％,89.5％,57.9％,and 90.5％,respectively,with statistically significant differences among these groups (P ＜ 0.05).Conclusion:ERK1/2 and p-ERK1/2 proteins are highly expressed in advanced PCa and p-ERK1/2 is associated with the metastasis and prognosis of advanced PCa.
Keywords：advanced prostate cancerERK1/2p-ERK1/2phosphorylationprognosis
Publication Date：2017-05-02
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 406-411 )