Yijingfang for the treatment of asthenospermia: A randomized controlled clinical trial
ZHANG Xiao-yi
LUO Shao-bo
ZHANG Jin-ying
MENG Zhe-cheng
Abstract：Objective:To investigate the clinical therapeutic effects of Yijingfang,a Chinese medicinal liquid,on asthenospermia.Methods:We randomly divided 450 asthenospermia patients into a treatment group (n =300) and a control group (n =150),the former treated with Yijingfang once half a dose,bid,and the latter with Wuziyanzong Pills (9 g,bid) + L-carnitine oral liquid (10 ml,bid),both for 3 months.Before and at 1,2,and 3 months after medication,we compared the semen volume,sperm concentration,percentages of progressively motile sperm (PMS) and total motile sperm (TMS),and semen liquefaction time between the two groups of patients.Results:No statistically significant difference was observed in the semen parameters between the treatment and control groups before medication (P ＞ 0.05).In comparison with the baseline,the treatment group showed significant differences at 1,2,and 3 months after medication in sperm concentration ([35.96 ± 8.50] vs [49.66 ± 10.91],[55.21 ± 11.46],[74.90 ± 13.07] ×106/ml,P ＜0.01),PMS ([19.72 ± 2.06] vs [23.81 ± 2.56],[26.12 ± 2.34],and [32.17 ± 1.62] ％,P ＜0.01) and TMS ([28.86 ± 2.70] vs [34.17 ± 3.43],[36.59 ± 3.36],and [47.08 ± 2.97] ％,P ＜0.01),butnot in the semen volume([3.35 ± 0.99] vs [3.15 ± 1.06],[3.12 ± 0.90],and [3.27 ± 0.78] ml,P ＞0.05) or semenliquefaction time ([32.31 ± 8.15] vs [31.68 ± 3.14],[30.38 ± 3.44],and [30.86 ± 2.42] min,P ＞0.05);the control group exhibited similar results at the three time points in sperm concentration ([36.85 ± 6.88] vs [40.53 ± 8.32],[47.51 ± 12.73],and [56.14 ± 11.98] ×106/ml,P ＜0.01),PMS ([20.26 ± 2.73] vs [25.17 ± 2.64],[27.23 ± 2.25],and [31.89±2.27] ％,P ＜0.01),andTMS ([30.03 ± 2.67] vs [33.89±2.26],[37.38±4.79],and [40.35±3.06] ％,P ＜0.01),but not in the semen volume ([3.03 ± 1.09] vs [3.16±1.78],[3.15±0.96],and [3.12±0.65] ml,P ＞0.05) or semen liquefaction time ([30.25 ± 5.20] vs [29.36±4.25],[28.21 ±3.26],and [28.33±3.59] min,P ＞0.05).There were statistically significant differences between the treatment and control groups in the increase rates of sperm concentration and TMS after medication (P ＜ 0.01) but not in that of PMS (P ＞ 0.05).Conclusion:Yijingfang is an effective drug for the treatment of asthenospermia,which can regulate the spermatogenesis,increase the percentage of PMS,and improve the total sperm motility of the patients.
Keywords：Yijingfangasthenospermiarandomized controlled trialclinical study
Publication Date：2017-04-02
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 361-366 )