Effects of Kudzu Root plus Cinnamon Granules on prostatic hyperplasia in mice
WANG An-xi
ZHU Xiao-yu
HUANG Ting
YANG Jin
CHENG Yi-dong
XU Yu-feng
Abstract：Objective:To explore the effects of Kudzu Root plus Cinnamon Granules (KR + C) on prostatic hyperplasia (PH) in mice.Methods:Sixty 4-week-old Kunming male mice were randomly divided into six groups:blank control,PH model,high-,medium-and low-dose KR + C,and finasteride control.All the mice except those in the blank control group were subcutaneously injected with testosterone propionate (5 mg / [kg · d]) at 7 days after surgical castration.The animals of different groups were treated intragastrically with different doses of KR + C,finasteride,and normal saline respectively for 3 weeks and then sacrificed for weighing of the prostate,calculation of the prostatic index,observation of the morphological changes in the prostate after HE staining,determination of the expressions of FGF2,Ki67 and TGF-β1 by immunohistochemistry,detection of 5α-reductase activity by ELISA,and measurement of the apoptosis index of the prostatic cells by TUNEL.Results:Compared with the model controls,the mice of the other groups showed significantly reduced prostatic volume (P ＜ 0.05),prostatic index (P ＜ 0.05),expressions of FGF2,Ki67 and TGF-β1,and activity of 5 α-reductase (P ＜ 0.05),but remarkably increased apoptosis index of the prostatic cells (P ＜ 0.05).However,no statistically significant differences were observed in the above parameters between the finasteride control and the three KR + C groups (P ＞ 0.05).Conclusion:KR + C can reduce the prostatic volume of PH mice by decreasing the activity of 5 α-reductase,inhibiting the expressions of FGF2,Ki67 and TGF-β1,and promoting the apoptosis of prostatic cells.
Keywords：Kudzu Root GranulesCinnamon Granulesprostatic hyperplasiaKunming micefinasteride
Publication Date：2017-04-02
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 353-360 )