Expressions of JNK and p-JNK in advanced prostate cancer and their clinical implications
ZHANG Peng
HAN Jian
ZHENG Lei
WANG Ke-nan
FAN Lian-ming
XIE Hua-dong
WANG Shu-ren
JIANG Tao
Abstract：Objective:To investigate the expressions of JNK and p-JNK in advanced prostate cancer (PCa) and benign prostatic hyperplasia (BPH) and their implications.Methods:Using immunohistochemistry,we detected the expressions of JNK and p-JNK proteins in 40 cases of paraffin wax-embedded PCa and 21 cases of BPH tissues and analyzed their relationships with advanced PCa and BPH as well as with the pathologic features of advanced PCa.Results:Statistically significant differences were not found in the positive expression rate of the JNK protein between BPH and PCa (42.86％ vs 52.50％,P ＞ 0.05),non-metastatic and metastatic PCa (53.85％ vs 51.85％,P ＞ 0.05),Gleason ≤7 and Gleason ＞ 7 (58.82％ vs 47.82％,P ＞ 0.05),PSA ≤20 μg/L and PSA ＞ 20 μg/L (57.14％ vs 51.52％,P ＞ 0.05),or survival ＞ 5 yr and survival ≤5 yr (60.00％ vs 45.00％,P ＞ 0.05),nor in the expression level of p-JNK between BPH and PCa (33.33％ vs 35.00％,P ＞0.05),non-metastatic and metastatic PCa (30.77％ vs 37.03％,P ＞0.05),Gleason ≤7 and Gleason ＞7 (35.29％ vs 34.78％,P ＞0.05),or PSA ≤20 μg/L and PSA ＞20 μg/L (43.75％ vs 10.93％,P ＞0.05).However,the expression of p-JNK was significantly higher in the survival ＞5 yr than in the sur vival ≤5 yr group of the PCa patients (50.00％ vs 20.00％,P ＜ 0.05).Conclusion:PCa patients with highly expressed p-JNKhave a longer survival time and the high positive rate of p-JNK is associated with the prognosis of PCa.
Keywords：prostate cancersurvival timeapoptosisphosphorylationjun N-terminal kinasephosphorylation jun N-terminal kinase
Publication Date：2017-04-02
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 309-314 )