Kangle Decoction for erectile dysfunction with liver-qi stagnation and kidney deficiency
Abstract：Objective:To observe the clinical efficacy of Kangle Decoction in the treatment of erectile dysfunction (ElD) with liver-qi stagnation and kidney deficiency.Methods:A total of 79 ED patients with liver-qi stagnation and kidney deficiency were randomly assigned to an experimental group (aged [36.62 + 8.05] yr and with a disease course of [18.15 + 6.41] mo) and a control group (aged [37.44 ±+ 8.10] yr and with a disease course of [17.51 ±+ 6.79] mo),the former treated orally with Kangle Decoction at 0.5 dose bid while the latter with Cialis at 10 mg qd alt,both for 8 weeks.Before treatment,after 4 and 8 weeks of medication,and at 4 weeks after drug withdrawal,we obtained the scores of the patients in the International Index of Erectile Function-5 (IIEF-5),Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS),and Short-Form Psychological and Interpersonal Relationship Scales (SF-PAIRS),and compared the indexes between the two groups of patients.Results:The IIEF-5 score was dramatically increased in both the treatment and control groups after 4 weeks (13.40 + 2.42 and 16.00 + 2.68) and 8 weeks of medication (18.60 + 3.50 and 18.59 + 3.80) and at 4 weeks after drug withdrawal (17.00 + 3.05 and 13.95 + 2.61) as compared with the baseline (10.78 ± 2.28 and 10.77 ±+2.33) (P ＜0.05),even higher in the treatment than in the control group after drug withdrawal (P ＜0.05).The EDITS scores in the treatment and control groups were (28.88 ± 3.31 and 28.90 ± 3.31) after 4 weeks of intervention,(29.68 ± 3.30 and 29.13 +±3.32) after 8 weeks of intervention,and (29.20 +±2.92 and 26.82 ±3.23) at 4 weeks after drug withdrawal,all significantly higher in the former than in the latter group after drug withdrawal (P ＜ 0.05).The sexual self-confidence score (SSCS),sexual spontaneity score (SSS),and sexual time-concern score (STCS) were all improved in the treatment and control groups after medication as compared with the baseline (P＜0.05),even higher in the former than in the latter group after drug withdrawal (P＜0.05) Conclusion:Kangle Decoction has a definite efficacy in the treatment of ED with liver-qi stagnation and kidney deficiency,with few adverse reactions and long-term post-withdrawal effect,and therefore deserves a wide clinical application.
Keywords：erectile dysfunctionKangle decoctioninternational index of erectile function-5erectile dysfunction inventory of treatment satisfactionpsychological and interpersonal relationship scales
Publication Date：2016-06-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)