Correlation of high-risk HPV 16/18 infections with prostate cancer

doi:10.13263/j.cnki.nja.2016.06.004

Abstract：Objective:To study the correlation of high-risk human papillomavirus 16 and 18 (HPV16/18) infections with the risk of prostate cancer (PCa) and their association with the clinicopathologic indexes of PCa.Methods:We collected tissue samples from 75 cases of PCa and 73 cases of benign prostatic hyperplasia (BPH).We detected HPV16/18 infections in the samples by immunohistochemistry and PCR combined with reverse dot blot (RDB) assay.Results:Immunohistochemistry revealed 16 cases of HPV16/18 positive in the PCa (21.3％) and 7 cases in the BPH samples (9.5％),with statistically significant difference between the two groups (P =0.049).PC R combined with RDB assay showed 17 cases of HPV16 infection (22.6％) and 13 cases of HPV18 infection (17.8％),including 4 cases of HPV16/18 positive,in the PCa group,remarkably higher than 6 cases of HPV16 infection (8.2％),3 cases of HPV18 infection (4.1％) and no HPV16/1 8 positive in the BPH controls (P =0.001).No significant differences were observed between the result of immunohistochemistry and that of PCR combined with RDB assay (P =0.069).The risk of HPV16/18 infections was found to be correlated with the clinical T-stage and Gleason score of PCa (P ＜ 0.05) but not with the patient's age,PSA level or lymph node metastasis (P ＞ 0.05).Conclusion:High-risk HPV16/18 infections are correlated with the risk of prostate cancer.