Efficacy and safety of vitamin D in the treatment of idiopathic oligoasthenozoospermia
DENG Xiao-lin
LI Yan-min
YANG xiao-yan
HUANG Jian-rong
GUO Shu-lin
SONG Le-ming
Abstract：Objective:To explore the efficacy and safety of vitamin D (VD) in the treatment of idiopathic oligoasthenozoospermia.Methods:This study included 86 infertilemen with idiopathic oligoasthenozoospermia,who were randomized to a VD and a control group of equal number,the former given oral VD 200 IU/d and calcium 600 mg/d,qd,while the latter administered oral vitamin E 100 mg and vitamin C 100 mg,tid.After 3 months of medication,we compared the semen parameters,adverse reactions,and pregnancy rate between the two groups.Results:After medication,the count of progressively motile sperm per ejaculate was increased from (9.82 ± 3.72) × 106 to (21.47 ± 6.52) × 106(P ＜ 0.05) and the proportion of progressively motile sperm from (18.41 ± 9.82) ％ to (28.27 ± 4.47) ％ (P ＜ 0.05) in the VD group.In comparison,the count of progressively motile sperm per ejaculate was elevated from (9.51 ± 6.31) × 106 to (12.36 ± 4.43) × 106 (P ＞ 0.05) and the proportion of progressively motile sperm from (17.79 ±5.25)％ to (21.35 ±2.41)％ (P＞0.05) in the control group.Pregnancy was achieved in 7 cases (16.3％) in the VD group,but only 1 case (2.3％) in the control (P ＜ 0.05).No adverse reactions were observed in either of the groups.Conclusion:Vitamin D,as a safe option for the treatment of idiopathic oligoasthenozoospermia,can effectively improve the semen quality,especially the progressive sperm motility of the patient.
Keywords：vitamin Didiopathic oligoasthenozoospermiamale infertilityefficacysafety
Publication Date：2014-11-16
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)