Protective effect of epigallocatechin gallate against sperm abnormality in mice
SUI Liu-cai
GE Yi-feng
XU Juan-juan
WU Rong-hua
FU Hai-yan
YAO Bing
Abstract：Objective:To investigate the protective effect of epigallocatechin gallate (EGCG) on mouse sperm in vivo.Methods:A total of 64 six-week-old male Kuming mice were randomly divided into eight groups of equal number to be treated with normal saline (negative control),Cyclophosphamide (CP) at 30 mg/kg (positive control),and CP followed by EGCG (experimental) at 20,40,and 80 mg/kg,respectively,given every other day for 10 days.At 4 and 5 weeks after treatment,the bilateral testes of the mice were harvested for examination of sperm abnormality.Results:EGCG did not increase the rate of CP-induced sperm abnormality in the mice,but reduced it instead with the prolonged time of treatment.Conclusion:EGCG protects mouse sperm in vivo
Keywords：epigallocatechin gallateCyclophosphamidesperm deformitymice
Publication Date：2014-11-16
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)