Phenotypic modulation of corpus cavernous smooth muscle cells and its influencing factors
CHEN Gang
Lü Bo-dong
HUANG Xiao-jun
Abstract：Corpus cavernous smooth muscle cells are the main functional component of the corpus cavernosum penis,whose phenotypic modulation is the key initial step in the proliferation and migration of smooth muscle cells. Therefore,an insight into the mechanism of the phenotypic modulation of smooth musclecells and its influencing factors is important for the prevention and manage ment of penis erectile dysfunction. Smooth muscle cells are generally divided into contracting (differentiated) and composing ( undifferentiated,proliferated or dedifferentiated) types. It is found that TGF-β transcription factor E2F1,BTEB2 and insulin may affect thephenotypic modulation of smooth muscle cells. This paper presents an overview of the progress in the researches on the phenotypic modulation of corpus cavernous smooth muscle cells and its influencing factors.
Keywords：corpus cavernosumsmooth muscle cellphenotype
Publication Date：2010-03-02
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 264-268 )