Azoospermia factor and male infertility
ZHANG Hua-jun
JIN Bao-fang
Abstract：Azoospermia factor (AZF) microdeletions of the Y chromosome, which occur in 1-55% of infertile men, are closely associated with severe spermatogenic failure and represent the most frequent molecular genetic causes of azoospermia and severe oligozoospermia. Researches on AZF and its related genes, approaching the mechanisms of spermatogenic failure at the molecular lev-el, are of great significance for the diagnosis, treatment and prognosis of male infertility. The detection of AZF microdeletions can pro-vide scientific basis for correct diagnosis and reasonable therapy. This article outlines the structure and functional characteristics of AZF, as well as its relationship with male infertility, cryptorchidism, varicocele, Klinefelter syndrome, seminoma, and recurrent abor-tion.
Keywords：AZFazoospermiamicrodeletionspermatogenic failuremale infertility
Publication Date：2010-01-31
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 166-169 )