Epididymal cyst in yon hippel-lindau syndrome: Clinicopathologic analysis of 3 cases
HOU Zhu
LUO Yong
JIANG Yong-guang
SHANG Jian-feng
CHEN Dong
Abstract：Objective: To investigate the clinicopathologic features of epididymal cyst in van Hippel-Lindau (VHL) syndrome.Methods: We reviewed the clinical data of 3 epididymal cyst patients treated by surgery, and detected the expressions of HIF-1α,VEGF, α-SMA and CD34 in the epididymal tissue samples by the immunohistochemistry SP method. Results: All the 3 patients un-derwent surgical removal of the epididymal cyst. Immunohistochemistry of the epididymal tissues showed HIF-1α, VEGF, α-SMA and CD34 to be positive. All the 3 cases were confirmed to be VHL syndrome, 1 right after surgery, and the other 2 within 8 years post-operatively. Conclusion: Epididymal cyst is a usual benign disease, which may occur independently of or be complicated by VHL syndrome. If immunohistochemistry of epididymal tissues shows HIF-1α, VEGF, α-SMA and CD34 to be positive, VHL syndrome should be considered, and further clinical examinations and post-operation follow-up are necessitated.
Keywords：epididymiscystyon Hippel-Lindau syndrome
Publication Date：2010-01-31
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 142-145 )