Reducing effect of curcumin on expressions of TNF-α，IL-6 and IL-8 in rats with chronic nonbacterial prostatitis
ZHANG Qing-yun
MO Zeng-nan
LIU Xi-di
Abstract：Objective:To investigate the effects of curcumin on the expressions of TNF-α,IL-6 and Ildg in rats with chronic nonbacterial prostatitis.Methods:Sixty healthy adult male SD rats with the body weight of 200-220 g were equally and randomly divided into a normal control,a positive control,a model,an oral curcumin and an intraperitoneal curcumin group.The rat models of chronic nonbacterial prostatitis were made by hypodermic injection of estradiol benzoate at the dose of 0.25 mg/(kg·d)for 30 days after castration,and then treated with cureumin at 200 mg/(kg·d)by gavage or intmperitoneal injection.The positive controls received oral celebrex at 250 mg/(kg·d),while the normal control and model groups were given saline by gavage.After a week of treatment,the levels of TNF-α,IL-6 and IL-8 in the serum and prostate tissues of the rats were detected by ELISA assay.Results:The levels of TNF-α and IL-8 in the serum and prostate tissues were significantly lower in the intraperitoneal curcumin than in the positive control group(P＜0.05),but the expression of IL-6 showed no significant difference between the two groups(P＞0.01).
Keywords：chronic nonbacterial prostatitiscurcumincytokinerat
Publication Date：2010-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 84-88 )