Expressions of bacterial 16S rRNA,IL-1β,TNF-αand NGF in prostate tissues
XIE Hui
HUANG Hui-tong
YANG Yi-rong
HE Qiu-xiang
ZHU Qi-jian
CHEN Jian-ou
Abstract：Objective:To investigate the role of bacteria in the etiology of chronic pmstatitis.Methods:A total of 162 complete prostate specimens were obtained at autopsy from organ donom(aged 20-38yr)who died of non-prostatic diseases.Each of the samples from the peripheral zone of the prostate was divided into two parts,one for routine pathological examination and immunohistochemical studies of interleukin(IL)-1β,tumor necrosis factor-α(TNF-α)and the nerve growth factor(NGF),and the other for PCR assay to detect the bacterial 16S rRNA gene(16S rDNA).Results:Fifty-one(31.5%)of the total specimens presented pathological changes of chronic prostatitis,of which 44 had mild focal stromal,5 mild focal stromal and periglandular and 2 mild focal periglandular inflammation.The positive rate of 16S rDNA was 19.1%(31/162),51.0%(26/51)in the chronic prostatitis and 4.5%(5/111)in the non-prostatitis specimens(χ~2=29.783,P＜0.01).In the specimens with chronic prostatitis,the expressions of IL-1β,TNF-αand NGF were significantly higher in the 16S rDNA positive than in the 16S rDNA negative group(P＜0.01).Conclusion:Bacterial inflammation may play an important role in the etiology of chronic prostatitis.
Keywords：prostatitis16S ribosomal RNAinterleukin-1βtumor necrosis factor-αnerve growth factor
Publication Date：2010-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 40-43 )