Arteriosclerotic risk factors and benign prostatic hyperplasia

SHEN Wen; YAO Hua-qiang; DENG Zhi-xiong; ZHANG Xiao-ming; ZHANG Li-chao; HU Wei-lie

Abstract：Objective:To evaluate the correlation between arteriosclerotic risk factors and the severity of benign prostatic hyperplasia(BPH).Methods:A total of 877 patients with diagnosed BPH were selected according to the inclusion criteria.The weight of the prostate was estimated by transrectal ultragonography,the degree of bladder outlet obstruction determined by urodynamic examination,and the symptoms quantified by the International Prostate Symptom Score(IPSS).Arteriosclerotic risk factors included age,hypertension,dyslipidemia,type 2 diabetes mellitus,and smoking.Comparative studies were made on the data obtained by univariate and multivariate analyses.Results:The severity of BPH was increased with the increase in the severity of the risk factors and the incidence of the disease.The logistic regression analysis showed that type 2 diabetes mellitus was a prominent predictor of the prostate volume,IPSS and degree of bladder outlet obstruction(OR=3.179,3.862 and 2.847,P＜0.001),while the level of serum triglyceride was not(P＞0.05).Age,hypertension,hish LDL,low HDL and smoking were all prominent predictors of the severity of BPH.Conclusion:Arteriosclerotic risk factors are obviously correlated with the development and severity of BPH,among which type 2 diabetes mellitus is the most important.