Microwave radiation decreases the expressions of occludin and JAM-1 in rats
GAO Xiao-fang
WANG Shui-ming
PENG Rui-yun
ZUO Hong-yan
WANG Li-feng
GAO Ya-bing
DONG Ji
SU Zhen-tao
Abstract：Objective:To explore the changes in the expressions of the tight junction related protein occludin and junctional adhesion molecule-1(JAM-1)of the blood-testis barrier and their significance in rats after microwave radiation.Methods:Eighty male Wistar rats"were exposed to microwave radiation with average power density of 0,10,30 and 100 mW/cm~2 for five minutes,and dynamic changes in the expressions of testicular oecludin and JAM-1 were observed by Western blot and image analysis at 6 h,1 d,3 d,7 d and 14 d after the radiation.Results:There was a significant down-regulation in the expression of the occludin protein at 3-7 d.6 h-7 d and 6 h-14 d(P＜0.05),as well as in that of JAM-1 at 3-7 d,1-7 d and 1-14 d(P＜0.05)after exposure to 10,30 and 100 mW/cm~2 microwave radiation.Conclusion:The decreased protein expressions of occludin and JAM-1 may play an imporrant roh in the microwave radiation induced-damage to the blood-testis barrier.
Keywords：microwave radiationblood-testis barrieroccludinjunctional adhesion molecule-1rat
Publication Date：2010-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 10-13 )