Expressions of Cadherin Molecules CDH18 and PCDH17 in Human Azoospermic Testes
YANG Bo
YUAN Jian-lin
GAO Xiao-kang
LIU He-liang
QIN Wei-jun
SHAO Chen
LIU Fei
KANG Fu-xia
Abstract：Objecave:To investigate the expressions of eadherin molecules CDH18 and PCDH17 in normal and azoospermic human testes and their significance. Methods:We studied the routine pathological slices of normal and non-obstructive azoospermic human testis tissues for changes in the tight junction of Sertoli-germ cells,and identified the differential gene expression profiles of the normal and azoospermic testis tissues using cDNA microarrays containing multiple cadherin molecules.The results were confirmed by Western blot. Results:Abnormal tight junction of the Sertoli-germ cells was observed in 37.5% of the azoospermic testis samples,and obvious changes were seen in the expressions of some eadherin molecules,with down-regulation of CDH18 and PCDH17. Conclu-sion:Cadberin molecules such as CDH18 and PCDH17 may play a certain role in the development and progression of azoospermia,which might be related with the abnormal tight junction of the Sertoli-germ cells.
Keywords：cadberinCDH18PCDH17tight junctionazoospermia
Publication Date：2009-11-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1081-1084 )