Combination of Tolterodine and Tamsulosm for Benign Prostatic Hyperplasia

WU Zong-lin; GENG He

Abstract：Objective:Overactive bladder may coexist with bladder oudet obstruction induced by benign prostatic hyperplasia(BPH).This study aimed to evaluate the efficacy of the combined uge of toherodine and tamsulosin in the treatment of BPH accompanied by overactive bladder.Methods:We selected 53 cages of clinically diagnosed BPH,and randomly assigned them to a tamsulosin group (n=25) to receive 0.2 mg of tamsulosin once a day and a tamsulosin+toherodine group(n=28)to be treated with 0.2 mg of ta-msulosin onee a day phs 2 mg of toheredine twice a day,both for 12 weeks.Before and after the treatment,we obtained the Interna-tional Prostate Symptoms Score(Ipss),quality of life(QOL) score and Qmas,and recorded the adverse events.Results:All the patients accomplisbed the 12-week treatment.The tamsulosin group showed a significant decrease in IPSS and QOL from 21.50 ±5.42 and 4.58±0.94 before the treatment to 14.80±4.21 and 2.78±0.91 after it(P<0.05),but a significant increase in Qmax from(12.20 ±6.60)ml/s to(16.40 ±5.13)ml/s (P<0.05).In the tamsulosin+toltereodine group,IPSS and QOL were decreased from 20.90 ±5.15 and 4.61 ±0.86 at the baseline to 14.90 ±5.32 and 2.12 ±0.87 after the medication(P< 0.05),Qmax was increased from(13.30 ±7.80)ml/s to(16.70±6.32)nl/s (P<0.05),and the score on the urinary stor-age phase symptoms was reduced from 10.12±3.10 to 4.77±0.75 (P<0.05).Conclusion:Tamsulosin could quicldy relieve BPH-induced lower urinary tract symptoms(LUTS),while the combined use of tolterodine and tamsulosin could even better alleviate tlle LUIS and improve the QOL of BPH patients.