Inhibitory Effect of TGJN on α1-Adrenoceptor of Human Hypertrophic Prostate in vitro
ShuWu ZHANG
DeGui CHANG
JiuYuan WANG
Kai GUO
JiChun SHAO
Abstract：Objectives: To evaluate the mechanism of using TGJN(a kind of extract of Chinese herb medicine)to treat BPH. Methods: The radioligandbinding assays were used to observe the inhibiting effect from TGJN to the α1-AR in human smooth muscle cells of hyperplastic prostate. Results: TGJN can inhibit the binding of α1-AR with 125 I BE through binding with α1-AR.The inhibition was related to the concentration of TGJN and the inhibition was the biggest in middle lobe of human hyperplastic prostate[The Ki was (200.3±19.83)mg/L]. Conclusions: TGJNcan inhibit the α1-AR in human smooth muscle cells of hyperplastic prostate. Natl J Androl,2001,7(2):136～138
Machine-generated Keywords：
Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 136-138，140 )