Advances in Phospholipid Hydroperoxide Glutathione Peroxidase and Sperm Maturation
WeiTao LI
WeiJie ZHU
ShanPei PAN
Abstract：The gene encoding selenoprotein phospholipid hydroperoxide glutathioneperoxidase (PHGPx) is located in chromosome 19 in human. PHGPx is the secondidentified as Se-dependent intracellular glutathione peroxidase (PHGPx) which is a19000(Mr), monomeric enzyme. PHGPx originally presumed to be a universal antioxidantenzyme protecting membrane lipids, appears to have adopted a variety of specificroles like silencing lipoxygenases and becoming an enzymatically inactive structuralcomponent of the mitochondrial capsule during sperm maturation. In other words,PHGPx exists as a soluble peroxidase in spermatids but persists in maturespermatozoa as an enzymatically inactive, oxidatively cross-linked, insolubleprotein. Natl J Androl,2001,7(2):109～112
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 109-112 )