Effect of Angelica Sinensis on NOS Activity in Penile Tissues of Rats after Crushing Injury to Cavernous Nerves
Abstract：Objectives: To explore the change of nitric oxide synthase (NOS)activity in penile tissues after crushing injury to cavernous nerves (CN) and the effect of local injection with Angelica Sinensis (AS) solution. Methods: Thirty male adult Sprague-Dawley rats were randomly divided into AS group, control group and normal group. Operations were conducted on the rats of the first two groups to build bilateral cavernous nerves injury models, then injections were given intrapelvically surrounding CN with 25% AS solution and 9.0g/L NaCl (10mg/kg) every day respectively. The normal group did not receive operation, but injection with 9.0g/L NaCl. 2 weeks later, NOS activity of each penile specimen was measured by spectrophotometrical technique. Results: The mean value of NOS activity of AS group was (1.360±0.139)U/mg．prot, which was 77.4% of the normal group and significantly higher than that of the control group [(0.945±0.098） U/mg．prot] which was only 53.8% of the normal group (P＜0.01). Conclusions: Crushing injury to CN could make NOS activity decrease in penile tissue and local injection with AS solution can avoid its decreasing in some extent. Ntl J Androl,2001，7（1）:29～31
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 29-31 )