Diagnostic efficiency of diffusion tensor imaging combined with amide proton transfer weighted imaging for early Parkinson's disease in the elderly
SU Xiangcun
LIAO Xin
CAI Lijun
WANG Yongfeng
ZHANG Qian
LIU Liqin
Abstract：Objective To investigate the diagnostic efficiency of combining diffusion tensor imaging(DTI)and amide proton transfer(APT)imaging for early Parkinson's disease(PD)in the elderly.Methods A total of 127 elderly patients(PD group)with early PD admitted in the Affiliated Hospital of Guizhou Medical University from June 2022 to June 2024 were enrolled,and another 113 healthy individuals who took physical examinations were also recruited and served as the control group.The general data were collected in the two groups.Both groups underwent multimodal magnetic resonance imaging(MRI),and received DTI and APT sequence scans.And DTI[mean diffusivity(MD),fractional anisotropy(FA)]and APT sequence parameters were collected and compared between groups.The diagnostic efficiency of DTI combined with APT for early PD in the elderly was analyzed by receiver operating characteristic(ROC)curve analysis.Results There were no statistical differences in MD,FA and magnetization transfer ratio asymmetry(MTRasym)values of the bilateral regions of interest(ROI)between the two groups.The PD group exhibited significantly higher DTI-MD values of the substantia nigra,red nucleus,putamen and globus pallidus than the control group(P＜0.05),and obvious difference was observed in the MTRasym value of the caudate nucleus head between two groups(P＜0.05).ROC curve analysis showed that the area under the curve(AUC)of DTI-MD values of the substantia nigra,red nucleus,putamen and globus pallidus combined with APT sequence caudate nucleus MTRasym value was 0.905(95％CI:0.865-0.945),significantly higher than that of single parameter(P＜0.05).Conclusion DTI and APT imaging have certain diagnostic efficiency for early PD in the elderly,and the combination of the two techniques can further enhance the diagnostic efficiency.
Keywords：Parkinson diseasediffusion tensor imagingamidesdiagnosis
Publication Date：2026-03-15
Online Publishing Date：2026-03-31(First online date of this platform, not the publication date of the document)
Pages：5( 372-376 )