Relationship of serum levels of CTRP5 and SCUBE1 with left ventricular remodeling and prognosis in elderly patients with acute myocardial infarction
LI Zhanhu
LI Yuan
JIN Bowei
YAN Xiaoju
ZHANG Hongbo
SU Yakun
LI Yong
Abstract：Objective To investigate the relationship between serum levels of complement C1q/tumor necrosis factor-related protein 5(CTRP5)and signal peptide-CUB-epidermal growth factor-like domain-containing protein 1(SCUBE1)and left ventricular remodeling(LVR)as well as prognosis in elderly patients with acute myocardial infarction(AMI).Methods A prospective study was conducted on 104 elderly AMI patients(study group)undergoing percutaneous coronary intervention(PCI),and another 50 age-matched patients with stable coronary artery disease(control group)admitted to our department between March 2022 and December 2023.Based on the occurrence of major adverse cardiovascular events(MACE)within 1 year of follow-up,the study group was further divided into a good prognosis subgroup(68 cases)and a poor prognosis subgroup(36 cases).Serum levels of CTRP5 and SCUBE1,as well as LVR parameters,were measured in all participants.Pearson correlation analysis was used to assess the relationship between CTRP5 and SCUBE1 levels and LVR indicators.Results The study group showed significantly higher serum levels of CTRP5 and SCUBE1,and higher left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic volume(LVESV),and left ventricular mass index(LVMI),and lower left ventricular ejection fraction(LVEF)compared to the control group(P＜0.01).Serum levels of CTRP5 and SCUBE1 were positively correlated with LVEDD,LVESV,and LVMI,and negatively correlated with LVEF in elderly AMI patients(P＜0.01).Higher serum CTRP5 and SCUBE1 levels were observed in the poor prognosis group than the good prognosis group(P＜0.01).ROC curve analysis indicated that the AUC value of combined CTRP5 and SCUBE1 in predicting prognosis was 0.914,which was significantly higher than that of CTRP5(AUC=0.759)or SCUBE1(AUC=0.836)alone(Z=12.719,9.237,P＜0.01).Killip class,LVESV,LVEF,NT-proBNP,cTnT,CTRP5,and SCUBE1 were influencing factors for prognosis in elderly AMI patients(P＜0.01).Conclusion Elevated serum levels of CTRP5 and SCUBE1 are associated with LVR and prognosis in elderly AMI patients,and their combination may serve as an effective indicator for predicting prognosis in these patients.
Keywords：myocardial infarctioncomplement C1qepidermal growth factorventricular remodeling
Publication Date：2026-03-15
Online Publishing Date：2026-03-31(First online date of this platform, not the publication date of the document)
Pages：5( 325-329 )