Relationship and clinical significance of plasma taurine up-regulated gene 1 and heart failure with preserved ejection fraction in elderly patients with essential hypertension
NING Liang
QI Heng
FANG Li
ZOU Bin
SHEN Zhijie
Abstract：Objective To investigate the clinical significance of plasma long non-coding RNA taurine up-regulated gene 1(lncRNA TUG1)in predicting the development of heart failure with preserved ejection fraction(HFpEF)in elderly patients with essential hypertension.Methods A prospective study was conducted on 75 elderly patients(HFpEF group)with HFpEF and essential hypertension admitted in our hospital from April 2022 to March 2025.Another 75 patients with essential hypertension but normal heart function were enrolled and served as control group.All patients underwent echocardiography,and plasma TUG1 level was measured using RT-qPCR.Results The plasma TUG1 level was significantly higher in the HFpEF group than the control group(P＜0.01).The plasma TUG1 level was positively correlated with aortic annulus diameter,left atrial diameter,left ventricular end diastolic and end systolic diameters,interventricular septal thickness,mitral E-wave to early diastolic mitral annulus velocity ratio,and left ventricular mass index,while it was negatively correlated with left ventricular fractional shortening,cardiac output,and left ventricular ejection fraction(P＜0.01).Plasma TUG1 was an risk factor for HFpEF occurrence(OR=1.136-1.314,P＜0.05).The AUC value of TUG1 in predicting HFpEF in hypertensive patients was 0.804,while the value of TUG1 combined with NT-proBNP or LVMI reached 0.883 and 0.855,respectively.Conclusion Elevated plasma TUG1 level is observed in the elderly patients with HFpEF and primary hypertension.TUG1 is considered as an effective biomarker for diagnosing the development of HFpEF in elderly patients with primary hypertension.
Keywords：essential hypertensionheart failureechocardiographytaurine up-regulated gene 1
Publication Date：2026-03-15
Online Publishing Date：2026-03-31(First online date of this platform, not the publication date of the document)
Pages：5( 315-319 )