Influencing factors for vascular aging in the elderly people
ZHAO Huan
SI Jin
SUN Lijie
ZHAO Ou
LUO Hongyu
MA Yixin
XIAO Keling
LI Jing
Abstract：Objective To investigate the relationship between the triglyceride-glucose(TyG)index and brachial-ankle pulse wave velocity(baPWV)in the elderly.Methods A total of 162 elderly inpatients with atherosclerotic cardiovascular disease(ASCVD)admitted to our department from October 2016 to August 2025 were enrolled as the ASCVD group,and another 125 elderly individuals who taking regular physical examinations in Department of Health Management of our hospital during the same period were selected as the non-ASCVD group.Basic clinical data and inflammatory and biochemical indicators were collected from all the participants.Estimated glomerular filtration rate(eGFR)and TyG index were calculated.The influencing factors of baPWV were analyzed in the two groups,respectively.Spearman correlation analysis and multiple linear regression analysis were employed to analyze the correlation between baPWV and clinical indicators.Results The ASCVD group exhibited significantly higher waist-hip ratio,TyG index,and proportion of antiplatelet agents use,while obviously lower ratio of males,diastolic blood pressure,and high-density lipoprotein cholesterol levels than the non-ASCVD group(P＜0.05,P＜0.01).In the non-ASCVD group,baPWV was positively correlated with age(r=0.366,P＜0.01),systolic blood pressure(SBP,r=0.352,P＜0.01)and TyG index(r=0.226,P＜0.05),and negatively with eGFR(r=-0.290,P＜0.01).In the ASCVD group,baPWV was positively correlated with age(r=0.448,P＜0.01),SBP(r=0.252,P＜0.01)and TyG index(r=0.167,P＜0.05),and negatively with eGFR(r=-0.255,P＜0.01)and body mass index(r=-0.203,P＜0.05).Stepwise multiple linear regression analysis identified age,SBP,TyG index,eGFR and hypertension as influencing factors for baPWV in the non-ASCVD group(P＜0.05,P＜0.01);whereas only SBP and age were influencing factors for baPWV in the ASCVD group(P＜0.05,P＜0.01).Conclusion In elderly population,baPWV is associated with age and SBP.TyG index is correlated with vascular aging in elderly non-ASCVD individuals,and is one of the important risk factors.
Keywords：vascular agingblood pressureTyG index
Publication Date：2026-03-15
Online Publishing Date：2026-03-31(First online date of this platform, not the publication date of the document)
Pages：4( 281-284 )