Diagnostic and prognostic values of SII combined with PNI for sepsis-induced cardiomyopathy in elderly patients

LI Shuo; ZHANG Yuanbo; ZHU Rui; WANG Zijing; HONG Xueyuan; JI Quanya; LIU Yu

doi:10.3969/j.issn.1009-0126.2026.02.014

Abstract：Objective To investigate the clinical value of systemic immune-inflammation index(SII)combined with prognostic nutritional index(PNI)in the diagnosis and prognosis of sepsis-induced cardiomyopathy(SIC)in the elderly.Methods A retrospective analysis was conducted on 168 elderly patients with sepsis admitted to Emergency ICU of Dongzhimen Hospital of Beijing University of Chinese Medicine from January 2020 to February 2025.Based on the results of echocardiography,they were divided into an SIC group(77 cases)and a control group(91 cases).The patients in the SIC group were further assigned into a survival subgroup(n=35)and a death subgroup(n=42)based on their 28-day outcomes.Clinical data were collected,and ROC curve analysis and Cox regression analysis were performed to evaluate the predictive efficiency of SII,PNI and other indicators for the prognosis of the SIC patients.Results The SIC group exhibited significantly higher ratios of hypertension,coronary heart disease,and renal dysfunction,and higher respiratory rate than the control group(P<0.05,P<0.01).SII,age and sequential organ failure assessment(SOFA)score were risk factors for cardiac dysfunction in sepsis patients(P<0.05).Obviously higher heart rate and respiratory rate were observed in the death subgroup than the survival subgroup(P<0.01).PNI was an independent risk factor for 28-day death in the SIC patients(HR=0.919,95%CI:0.861-0.980,P<0.05).ROC curve analysis revealed that the AUC value of SII/PNI ratio in predicting the death in SIC patients was 0.730.Conclusion High SII is an independent risk factor for developing SIC in patients with sepsis,and low PNI is an independent predictor of death in patients with SIC.SII/PNI ratio has certain predictive value for death in SIC patients.