Effect of IL-17/IL-23 immune-inflammatory axis on ventricular remodeling and prognosis in elderly patients with coronary heart failure

LU Yinping; YANG Yapan

doi:10.3969/j.issn.1009-0126.2026.01.005

Abstract：Objective To explore the impact of IL-17/IL-23 on ventricular remodeling and prognosis in elderly coronary heart disease(CHD)patients with heart failure(HF).Methods A total of 120 elderly patients with concomitant CHD and HF undergoing PCI in Nanyang First People's Hospital from May 2021 to May 2024 were recruited and served as the study group.They were further divided into a poor prognosis group(21 cases)and a good prognosis group(99 cases)based on their survival status during the 12-month follow-up.Another 100 elderly healthy individuals who taking physical exams in the same hospital during the same period were enrolled and taken as a control group.Ventricular remodeling indicators,including left ventricular posterior wall thickness(LVPWT),left ventricular end-diastolic diameter(LVEDD),and left ventricular ejection fraction(LVEF),were measured.Pearson correlation analysis was used to determine the correlation between serum IL-17 and IL-23 levels and ventricular remodeling indicators.Logistic regression analysis was conducted to identify factors influencing the prognosis of the elderly CHD patients with HF.ROC curve analysis was performed to evaluate the predictive value of serum IL-17 and IL-23 expression for the prognosis of the elderly patients.Results Significantly higher IL-17 levels,elevated LVPWT and LVEDD values,and lower LVEF value were observed in the study group than the control group(P<0.01).Pearson correlation analysis showed that IL-17 was positively correlated with LVPWT and LVEDD values(r=0.415,r=0.380,P<0.01),and both the two indicators were negatively correlated with LVEF(r=-0.392,P<0.01).The poor prognosis group had significantly lower LVEF and higher IL-17 and IL-23 levels than the good prognosis group(P<0.01).Elevated serum IL-17 and IL-23 levels were risk factors for poor prognosis in the elderly CHD patients with HF(P<0.05).ROC curve analysis showed that the AUC value of combined IL-17 and IL-23 was significantly higher than the AUC value of the indicator alone in predicting the prognosis of the elderly patients(0.961 vs 0.813,0.887,P<0.01).Conclusion The serum expression of IL-17 and IL-23 in the IL-17/IL-23 axis is associated with ventricular remodeling and prognosis in the elderly CHD patients with HF after PCI,and the two indicators have certain predictive value for the prognosis of these patients.