Relationship between gene polymorphisms of TNF-α and IL-6 and nosocomial infection in elderly patients with acute myocardial infarction after percutaneous coronary intervention
GONG Chu
JIANG Wen
ZHANG Yang
DU Minjie
YILIMINUER Yimingjiang
ZHANG Yuxiang
Abstract：Objective To explore the correlation of nosocomial infection after percutaneous coronary intervention(PCI)with gene polymorphisms of serum TNF-α and IL-6 in patients with acute myocardial infarction(AMI).Methods Clinical data of 210 AMI patients undergoing PCI in our hospital from December 2021 to December 2024 were collected and retrospectively analyzed.Based on postoperative infection status,the patients were divided into an infection group(n=39)and a non-infection group(n=171).According to the severity of the infection,the infection group was further assigned into a severe subgroup(11 cases)and a mild subgroup(28 cases).The risk factors of postoperative nosocomial infection were analyzed.The polymorphisms of serum TNF-α and IL-6 genes were compared between the infection group and non-infection group,and the relationship with infection occurrence was analyzed.The evaluation value of gene polymorphisms of TNF-α and IL-6 for the severity of infection was analyzed in AMI patients after PCI.Results The infection group exhibited significantly larger proportions of surgical time≥1 h,diabetes mellitus,chronic bronchitis and invasive procedures,higher levels of TNF-α and IL-6,and smaller proportion of prophylactic use of antibiotics than the non-infection group(P<0.05,P<0.01).Multivariate logistic regression analysis indicated that surgical time≥1 h(OR=2.063,95%CI:1.301～3.269,P<0.01),diabetes mellitus(OR=1.432,95%CI:1.138～1.801,P<0.01),chronic bronchitis(OR=2.472,95%CI:1.183～5.165,P<0.05)and invasive procedures(OR=2.261,95%CI:1.043～4.905,P<0.05)were risk factors of nosocomial infection after PCI in AMI patients,and prophylactic use of antibiotics was a protective factor(OR=0.311,95%CI:0.159～0.610,P<0.01).The polymorphisms of serum TNF-α and IL-6 genes were in line with Hardy-Weinberg equilibrium in both groups(P>0.05).The detection rates of GA and AA at rs1799724 locus of TNF-α and CG and GG at rs2249825 locus of IL-6 were notably higher in the infection group than the non-infection group(P<0.05).The gene polymorphism at rs1799724 locus of TNF-α was an influencing factor of nosocomial infection in AMI patients after PCI(P<0.01).The detection rates of GA and AA at rs1799724 locus of TNF-α and CG and GG at rs2249825 locus of IL-6 were higher in the severe subgroup than the mild subgroup(P<0.05,P<0.01).The area under the ROC curve of TNF-α gene polymorphisms at rs1799724 locus in assessing severity of infection was greater than that of IL-6 gene polymorphisms at rs2249825 locus(P<0.01).Conclusion Surgical time≥1 h,diabetes mellitus,chronic bronchitis and invasive procedures are risk factors of nosocomial infection in AMI patients after PCI.The polymorphisms of TNF-α gene at rs1799724 locus are associated with nosocomial infection in the patients.
Keywords：myocardial infarctionpercutaneous coronary interventiontumor necrosis factor-αinterleukin-6nosocomial infection
Publication Date：2026-01-15
Online Publishing Date：2026-01-16(First online date of this platform, not the publication date of the document)
Pages：5( 9-13 )