Relationship between relevant serum biomarkers and clinical outcomes in STEMI patients after PCI
AN Yuezhen
YU Qian
LIU Shuai
WANG Jiawang
GUO Jinping
WEI Zhijie
ZHANG Lei
Abstract：Objective To explore the relationship between the levels of serum nesfatin-1(NSF-1),chitinase protein 40(YKL-40),and lipoprotein-associated phospholipase A2(Lp-PLA2)and left ventricular remodeling as well as clinical outcomes in patients with ST-segment elevation myocardial infarction(STEMI)after percutaneous coronary intervention(PCI).Methods A total of 123 STEMI patients undergoing PCI in our hospital from September 2024 to January 2025 were prospectively enrolled.They were divided into a good prognosis group(78 cases,including recovery and improvement)and a poor prognosis group(45 cases,including deterioration and death)based on the clinical outcomes of 6-month follow-up.The left ventricular remodeling indicators and the levels of serum NSF-1,YKL-40,and Lp-PLA2 were compared between the two groups.Pearson correlation analysis was used to analyze the correlation between the serum levels of above biomarkers and left ventricular remodeling indicators in STEMI patients after PCI.Multivariate logistic regression analysis was used to identify the risk factors affecting the prognosis of STEMI patients after PCI.ROC curve analysis was used to evaluate the predictive value of above serum biomarker levels for prognosis.Results The left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV),and serum levels of YKL-40 and Lp-PLA2 were significantly higher,while left ventricular ejection fraction(LVEF)and NSF-1 level were obviously lower in the poor prognosis group than the good prognosis group(P<0.01).Pearson correlation analysis showed that in the STEMI patients after PCI,the serum NSF-1 level was negatively correlated with LVEDV and LVESV and positively with LVEF(P<0.01);the serum YKL-40 and Lp-PLA2 levels were positively correlated with LVEDV and LVESV and negatively correlated with LVEF(P<0.01).Multivariate logistic regression analysis showed that NSF-1 was a protective factor for the prognosis of STEMI patients after PCI,while YKL-40 and Lp-PLA2 were independent risk factors(P<0.05,P<0.01).ROC curve analysis revealed that the AUC value of the combined prediction of serum NSF-1,YKL-40,and Lp-PLA2 for the prognosis of STEMI patients after PCI was significantly higher than that of single predictions(0.917 vs 0.864,0.807,0.778,P<0.01).Conclusion The serum levels of NSF-1,YKL-40 and Lp-PLA2 are related to left ventricular remodeling and clinical outcomes in STEMI patients after PCI.Their combination shows better prediction for poor prognosis.
Keywords：ST elevation myocardial infarction1-alkyl-2-acetylglycerophosphocholine esterasenesfatin-1
Publication Date：2026-01-15
Online Publishing Date：2026-01-16(First online date of this platform, not the publication date of the document)
Pages：5( 4-8 )