Research Progress on the Relationship between Neutrophil Extracellular Traps and Myocardial Infarction
Abstract：In recent years, studies have found that neutrophils release a substance called neutrophil extracellular traps (NETs), which is a biologically active network composed of intracellular DNA, histones, and granular proteins. NETs have played an immune role in cancer and autoimmune diseases [1-2]. In myocardial infarction, the role of neutrophils has been underestimated due to their short survival time in the blood. Although the mortality rate of myocardial infarction has significantly decreased with the popularization of percutaneous coronary intervention (PCI), the incidence of complications and hospitalization rates remain high. Reperfusion injury after PCI is also an important cause [3-4]. Studies have found that during the formation of NETs, large amounts of reactive oxygen species (ROS) can be generated through the NADPH oxidase pathway and mitochondrial pathway, participating in the pathophysiological processes of lipid oxidation deposition, endothelial dysfunction, myocardial injury, and ischemia-reperfusion injury in myocardial infarction. This establishes a new link between oxidative stress and myocardial infarction. This review aims to explore the role and related mechanisms of NETs in exacerbating oxidative stress injury and thereby aggravating myocardial infarction.
Keywords：Myocardial InfarctionReactive Oxygen SpeciesOxidative StressLipoproteinsLDL
Publication Date：2025-12-15
Online Publishing Date：2025-12-29(First online date of this platform, not the publication date of the document)
Pages：4( 1765-1768 )